Chromatography Market Size 2024-2028

The global chromatography market size is estimated to grow by USD 3.99 billion at a CAGR of 6.78% between 2023 and 2028. The growth of the market depends on several factors, including the increasing number of conferences and symposiums, the increasing number of research institutes and companies offering these training courses, and the increasing demand for ion exchange membranes in R&D. Furthermore, the market is also driven by a wide range of technologies and applications, including flow management accessories, chromatography fittings and tubing, and fraction collectors, enabling efficient separation and analysis of complex mixtures. Essential components such as solvents/reagents/adsorbents and mobile phase accessories ensure optimal performance, while pressure regulators maintain system stability. The market also sees demand for prepacked columns and empty columns to accommodate various sample types. It also includes an in-depth analysis of drivers, trends, and challenges.

What will be the Size of the Market During the Forecast Period?

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Key Companies & Market Insights

Companies are implementing various strategies, such as strategic alliances, partnerships, mergers and acquisitions, geographical expansion, and product/service launches, to enhance their presence in the market. The report also includes detailed analyses of the competitive landscape of the market and information about key companies, including:

Agilent Technologies Inc., Bio Rad Laboratories Inc., Centurion Scientific, Danaher Corp., Hamilton Co., Hitachi Ltd., Merck KGaA, Perkin Elmer Inc., Regis Technologies Inc., Restek Corp., Sartorius AG, Scientific Repair Inc., SCION Instruments NL BV, Shimadzu Corp., Siemens AG, Thermo Fisher Scientific Inc., Tosoh Corp., Valco Instruments Co. Inc., Waters Corp., and ZirChrom Separations Inc.

Agilent Technologies Inc.- The company offers Gas Chromatography and Liquid Chromatography.

Qualitative and quantitative analysis of companies has been conducted to help clients understand the wider business environment as well as the strengths and weaknesses of key market players. Data is qualitatively analyzed to categorize companies as pure play, category-focused, industry-focused, and diversified; it is quantitatively analyzed to categorize companies as dominant, leading, strong, tentative, and weak.

Market Segmentation 

The chromatography market is driven by diverse applications, including partition chromatography, size exclusion chromatography, and column chromatography, addressing needs in sectors like the petroleum industry and biotechnology. While chromatography equipment can be expensive, its efficiency and ability to meet stringent quality standards make it indispensable in pharmaceuticals, environmental science, and healthcare. Advances in technological capabilities have led to innovations such as miniaturization and portable chromatography systems, facilitating point-of-care testing and on-site analysis. With a focus on accurate and reproducible results, the market offers a range of solutions including column accessories, detectors, and automated sample handling to meet the demands of research and development activities, quality control, and regulatory standards in various industries.

By Technology 

The market share growth by the liquid chromatography segment will be significant during the forecast period. This was the largest segment of the global market in 2020. It is an important analytical technique used for the separation, identification, and quantification of small molecules in a mixture. The adoption of liquid market systems is increasingly driven by the pharmaceutical industry to analyze the composition of raw materials used in the development of novel drugs aimed at curing specific diseases and the purification of drug components and recombinant proteins and antibodies. 

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The liquid chromatography segment showed a gradual increase in the market share of USD 4.21 billion in 2018. The use of this is also significant in deoxyribonucleic acid (DNA) fingerprinting and bioinformatics. High-performance liquid chromatography is specifically used in protein isolation, including insulin purification, plasma fractionation, and enzyme purification. Thus, the wide range of applications and benefits of this in pharmaceutical, metabolomics, clinical, and proteomic analysis has led to the growth of this segment.

Regional Analysis

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North America is estimated to contribute 45% to the growth of the global market during the forecast period. Technavio’s analysts have elaborately explained the regional trends and drivers will shape the market during the forecast period. The US was followed by Canada in terms of contributions to the growth. Research laboratories and government bodies such as Defence Research and Development Canada (DRDC) are currently working on discovering new sampling techniques and column heating approaches to expand and improve the efficiency of these systems for the detection and identification of unknown chemicals in field settings. They are also using field these systems for analyzing water and air samples using newer techniques, such as resistively heated analytical columns, for higher performance on the field. Moreover, the presence of leading suppliers such as Canadian Life Science, which offers chromatography, dissolution, and spectroscopy essentials, is benefitting market growth in Canada.

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Market Dynamics and Customer Landscape

The chromatography market continues to evolve with advancements like high-pressure liquid chromatography, ultra-pressure liquid chromatography, and flash chromatography offering improved separation techniques. These innovations address diverse needs across industries such as pharmaceutical R&D, food safety concerns, and the oil & gas industry in combating environmental pollution. While chromatography equipment is costly, its advanced features and functionalities justify the investment. The market caters to a wide range of users, from small- & medium-sized companies to academic institutions, with solutions like capillary columns and gas chromatography columns optimizing analytical performance. Protein therapeutics and petrochemical applications drive demand, with alternative techniques continually explored to enhance manufacturing cost and volume. The Increasing demand for ion exchange membranes for this in R&D is notably driving the market growth, although factors such as product limitations the market growth. Our researchers analyzed the data with 2022 as the base year, along with the key drivers, trends, and challenges. A holistic analysis of drivers will help companies refine their strategies to gain a competitive advantage.

Key Market Driver

The increasing demand for ion exchange membranes in R&D is the key factor driving the global market. It plays a crucial role in the purification of biopharmaceuticals. The downstream process of the biopharmaceutical industry requires this technology, which involves significant time and cost. Hence, there is consistent pressure to improve the productivity and efficiency of these processes.

Several developments in large-scale processes have been witnessed in the market, including the development of new resin properties, for instance, enhancing Protein A for use in capturing mAb, implementing single-use technologies, exploring the continuous potential of these on a commercial scale, and the increasing use of automation as ion exchange membranes play an important role in this technology. Thus, with the increasing demand for ion exchange, the market is expected to witness growth during the forecast period.

Significant Market Trends

The new developments in the industry are the primary trend in the global market. companies are increasingly focusing on strategic developments such as product innovations to extend their product portfolios and ensure the availability of these products among end-users, such as research laboratories and academic institutes. The key strategies adopted include the launch of new products, product approvals, joint ventures, acquisitions, partnerships, expansion projects, collaborations, and new investments.

For instance, in May 2022, Thermo Fisher Scientific Inc. opened its new single-use technology manufacturing site in Utah, USA. The company (Thermo Fisher) also launched the Thermo Scientific SureStart portfolio for this technology and mass spectrometry consumables in February 2022. Thus, the growing number of developments is expected to support the growth of the market during the forecast period

Major Market Challenge

High energy consumption of compact embedded products is a major challenge to the global market. These systems have certain limitations that are hampering the growth. For instance, the lack of a universal detector in high-HPLC to distinguish a diverse range of analytes from a given chromatographic eluent has led to the inability of HPLC to generate adequate sensitivity for analytes. Moreover, HPLC has low sensitivity toward certain compounds, wherein the compounds cannot be detected, as they are irreversibly adsorbed. Also, due to the presence of a large array of different molecules, columns, and mobile phases, it is extremely complex to troubleshoot problems or develop new methodologies in HPLC.

Moreover, many portable gas chromatography systems have no provision for heating the column, detector, or injection port required for better analysis, thereby limiting analyses to the more volatile compounds. Since these systems do not have heated injection ports, unlike laboratory-type gas systems, the sample must be a gas or vapor at room temperature, which restricts the analysis of other sample types. Such product limitations can pose a challenge to the growth of the market during the forecast period.

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Market Customer Landscape

The market forecast report includes the adoption lifecycle of the market, covering from the innovator’s stage to the laggard’s stage. It focuses on adoption rates in different regions based on penetration. Furthermore, the market report also includes market growth analysis, market growth and forecasting, key purchase criteria, and drivers of price sensitivity to help companies evaluate and develop their market forecasting and growth strategies.

 Customer Landscape

Segment Overview

The market research report provides comprehensive data (region-wise segment analysis), with forecasts and estimates in "USD Billion" for the period 2024-2028, as well as historical data from 2018 - 2022 for the following segments.

• Technology Outlook 
  • Liquid chromatography
  • Gas chromatography
  • Ion-exchange chromatography
  • Other chromatography
• End-User Outlook 
  • PBC
  • RFAI
  • Others
• Region Outlook 
  • North America
    • The U.S.
    • Canada
  • Europe
    • The U.K.
    • Germany
    • France
    • Rest of Europe
  • Asia
    • China
    • India
  • Rest of the World
    • Chile
    • Argentina
    • Brazil

Market Analyst Overview

Chromatography is a crucial technique used in various industries, such as Agriculture, Pharmaceutical Firms, and Clinical Research Organizations, for separating and analyzing complex mixtures. It involves different types of systems, including Liquid, Fluid, and Thin Layer Chromatography systems, along with the use of Solvents, Reagents, and Adsorbents. The market encompasses a diverse array of technologies, including medium-pressure liquid chromatography systems and specialized gas chromatography columns, catering to the needs of various industries such as pharmaceuticals and environmental science. While the high cost of chromatography equipment may pose challenges, advancements in chromatographic efficiency and manufacturing volume have enhanced accessibility. Processes like equilibration, wash, elution, and regeneration ensure optimal performance and longevity of chromatography systems, while sanitization protocols maintain cleanliness and reliability. Despite challenges, the market continues to evolve, driven by demand for accurate analytical instruments and reproducible results across sectors, emphasizing the importance of chromatography in research, quality control, and regulatory compliance.

Key components of chromatography systems include Syringes, Needles, and various Accessories like column and auto-sampler accessories. Pumps are essential for delivering the mobile phase in chromatographic separations. This technology plays a vital role in various applications, such as Environmental Testing and Drug Development, including downstream processing. It is used in research areas like the study of Acute Respiratory Distress Syndrome (ARDS) and cancer, supported by organizations like the American Cancer Society. Leading companies like Novasep Process SAS offer innovative solutions like the GC 2400 Platform. The market is segmented based on industry needs, with prominent players driving advancements in this technology.

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What are the Key Data Covered in this Market Research and Growth Report?

• CAGR of the market during the forecast period
• Detailed information on factors that will drive the growth of the between 2024 and 2028
• Precise estimation of the size of the market and its contribution in focus to the parent market
• Detailed analysis of customer landscape covering diver of price sensitivity, adoption of the lifecycle, and key purchase criteria 
• Companies landscape comparing criticality of inputs and factors of differentiation
• Exclusive Matrix on companies position and classification
• Accurate predictions about upcoming trends and changes in consumer behavior
• Growth of the market across North America, Europe, Asia, and Rest of World (ROW)
• Thorough analysis of the market’s competitive landscape and detailed information about companies
• Comprehensive analysis of factors that will challenge the growth of companies