Affinity Chromatography Reagents Market Size 2024-2028

The  Affinity Chromatography Reagents Market size is estimated to grow by USD 610.7 million at a CAGR of 10.68% between 2023 and 2028. The market is experiencing significant growth due to several key factors. Firstly, the increasing research and development in the biopharmaceutical industry is driving market expansion. This sector relies heavily on affinity chromatography for the purification of biomolecules, particularly therapeutic antibodies. Additionally, stringent regulations regarding purity standards in pharmaceuticals and biotechnology are fueling the demand for high-quality affinity chromatography reagents. Furthermore, the rising trend of personalized medicine and the development of novel therapeutic targets are expected to provide further growth opportunities for this market. However, challenges such as high production costs and the need for specialized equipment may hinder market growth to some extent. Overall, the market is for strong growth in the coming years, driven by the increasing demand for purified biomolecules in the biopharmaceutical industry.

What will be the size of the Market During the Forecast Period?

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Market Segmentation

By Application 

The Pharmaceutical and Biotechnology Industry is estimated to witness significant growth during the forecast period. Affinity chromatography reagent manufacturers are highly concentrating on drug research and development, owing to the extensive application of affinity chromatography in drug affinity screening and the isolation and purification of protein, amino acids, and antibodies with the help of various affinity media. Some of the commonly used affinity media are amino acid media, carbohydrate bonding media, and hydrophobic interaction media. Affinity chromatography has enabled pharmaceutical and biotechnology product manufacturers to remove specific contaminants, achieve faster separation of complex molecules, and attain high purity standards for protein synthesis, usually in a single-step process in the research and development of drug/biosimilars. Growth in drug research and development and the rising number of clinical trials propel the demand for affinity chromatography reagents in the pharmaceutical and biotechnology industries. Some of the key applications of analytical chromatography reagents include separation in industry and academia as well as quantitation and identification of chemical or biological compounds.

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The Pharmaceutical and Biotechnology Industry was the largest segment and was valued at USD 353.60 million in 2018. A rise in clinical trials for drugs and biosimilars related to chronic diseases such as cancer, neural diseases, and Alzheimers disease has increased pipeline projects. Many antibody therapeutics are entering clinical studies and getting approved. In the US, there were over 20,000 prescription drug products approved for marketing. Most of these approvals were for oncology-based therapies. The increased clinical trials, specifically for antibody therapies and biosimilars, drive the demand for affinity chromatography procedures in the pharmaceutical and biotechnology industries and offer growth opportunities to affinity chromatography reagent manufacturers during the forecast period.

By End-User 

Pharmaceutical and biotechnology industry

There is an increasing focus by affinity chromatography reagent manufacturers on drug R&D, due to the various applications of affinity chromatography in drug screening and the isolation and purification of protein, amino acids, and antibodies with the help of different affinity media. Amino acid media, carbohydrate bonding media, and hydrophobic interaction media are some of the commonly used affinity media. There is increasing adoption of affinity chromatography across pharmaceutical and biotechnology product manufacturing in order to remove specific contaminants, achieve faster separation of complex molecules, and attain high-purity synthesis. Hence, such factors are expected to fuel the growth of this segment which, in turn, will drive the market growth during the forecast period. 

Food and beverage industry

One of the main applications of affinity chromatography reagents in the food and beverage industry is to detect and separate contaminants and toxic compounds from food products to ensure food safety. For instance, immunoaffinity chromatography is extensively utilized in food and beverage industries as it leverages a highly selective approach for the separation of a targeted compound using antibodies. Furthermore, other applications include the isolation and extraction of mycotoxins (fungal toxins) from contaminated food products. Hence, such factors are expected to fuel the growth of this segment which, in turn, will drive the market growth during the forecast period.

By Region

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North America is estimated to contribute 41% to the growth of the global market during the forecast period. Technavio's analysts have elaborately explained the regional trends and drivers that will shape the market during the forecast period. Some of the key factors which are significantly contributing to the market in North America are the increasing focus on drug development and research, the rising approval of monoclonal antibody-based therapies, and the presence of many key affinity chromatography reagent manufacturers. Additionally, there is increasing adoption of affinity chromatography reagents in the pharmaceutical and biotechnology sector due to the increasing approval of therapeutic monoclonal antibodies in the US.

Key Market Players 

Companies are implementing various strategies, such as strategic alliances, partnerships, mergers and acquisitions, geographical expansion, and product/service launches, to enhance their presence in the market. The report also includes detailed analyses of the competitive landscape of the market and information about 20 market companies, including:

Agilent Technologies Inc: The company offers affinity chromatography reagents such as filters for gel matrices.

AMS Biotechnology Europe Ltd., Avantor Inc., Bio Rad Laboratories Inc., Hamilton Bonaduz AG, Helena Laboratories Corp., Kaneka Corp., Kanto Chemical Co. Inc., Loba Chemie Pvt. Ltd., Merck KGaA, PerkinElmer Inc., Promega Corp., QIAGEN NV, Regis Technologies Inc., Santa Cruz Biotechnology Inc., Sartorius AG, Thermo Fisher Scientific Inc., Waters Corp., Shimadzu Corp., and Tosoh Corp.

Qualitative and quantitative analysis of companies has been conducted to help clients understand the wider business environment as well as the strengths and weaknesses of key market players. Data is qualitatively analyzed to categorize companies as pure play, category-focused, industry-focused, and diversified; it is quantitatively analyzed to categorize companies as dominant, leading, strong, tentative, and weak.

Market Dynamics and Customer Landscape

The market is a significant segment of the Bioprocessing industry, catering to the needs of Biopharmaceuticals, Life Sciences Research, Personalized Medicine, Biotechnology, and Biopharmaceutical production. These reagents play a crucial role in Separation and Purification processes, particularly for Biomolecules such as proteins, nucleic acids, and other Bioprocessing workflows. Affinity Chromatography relies on Ligands that selectively bind to Target Molecules, enabling their Isolation and Purification. These reagents find extensive applications in various sectors, including Clinical diagnostics, Healthcare, Biotechnology Industry, Cosmetic Industry, and Environmental Pollution. The market for Affinity Chromatography Reagents is driven by the growing Research activities in these sectors and the increasing demand for specialized training and Alternative Analytical Methods. Quality Control in Biopharmaceutical production and Analytical Instruments like Gas Chromatography, Mass Spectrometry, Thin Layer Chromatography, and Buffers are essential components of this market.

Key Market Drivers

One of the key factors driving the market growth is the adoption of automation in affinity chromatography. The main issue associated with the manual procedures in protein purification and manufacturing techniques is that it is labor-intensive and time-consuming. Furthermore, several liquid chromatography-based systems are expensive and complex to learn. Therefore, many manufacturers are providing automated solutions for performing affinity chromatography. 

Furthermore, the main advantage of such solutions is that it is less expensive and are easy to learn. Hence, it has resulted in the emergence of fast, reliable, and cost-effective protein purification techniques that have high analytical precision and high quantitative recovery. which is expected to drive market growth during the forecast period.

Significant Market Trends

A key factor shaping the affinity chromatography reagents market growth is the increasing focus on advanced, faster, and cost-effective purification technologies. An increase in the number of protein-based therapies has facilitated the development of cost-effective, faster, and efficient chromatographic workflow among end-users, including the pharmaceutical and biotechnology industries.

Furthermore, there is an increasing preference for products with short time-to-market among end-users as the protein therapeutics market is highly competitive. Furthermore, several market players are launching advanced reagents that have high binding capabilities and provide a reduction in time to perform the chromatography process when compared to traditional resins. Hence, such factors are expected to drive market growth during the forecast period.

Major Market Challenges

The high cost of resins used in affinity chromatography is one of the key challenges hindering the market growth during the forecast period. The use of high-priced resins for lining the columns are significantly contributing to the overall cost of the affinity chromatography procedure. These resins typically comprise beaded agarose coupled with capturing proteins such as Protein A and G.

Furthermore, several advanced costs are approximately between USD 11,000 and USD 12,000 per liter. Additionally, entrapping resins used in affinity purification are utilized for protein synthesis and antibody manufacturing and the cost of this procedure can range from 25% to 30% of the overall cost. Hence, such factors are expected to hinder market growth during the forecast period.

Key Market Customer Landscape

The market report includes the adoption lifecycle of the market, covering from the innovator's stage to the laggard's stage. It focuses on adoption rates in different regions based on penetration. Furthermore, the report also includes key purchase criteria and drivers of price sensitivity to help companies evaluate and develop their growth strategies.

Global Market Customer Landscape

Segment Overview

The market research report provides comprehensive data (region wise segment analysis), with forecasts and estimates in "USD Million" for the period 2024 to 2028, as well as historical data from 2018 to 2022 for the following segments.

• Application Outlook 
  • Analytical chromatography reagents
  • Preparative chromatography reagents

• End-user Outlook 
  • Pharmaceutical and biotechnology industry
  • Food and beverage industry
  • Cosmetic industry
  • Others
• Region Outlook 
  • North America
    • The U.S.
    • Canada
  • Europe
    • The U.K.
    • Germany
    • France
    • Rest of Europe
  • APAC
    • China
    • India
  • South America
    • Chile
    • Argentina
    • Brazil
  • Middle East & Africa
    • Saudi Arabia
    • South Africa
    • Rest of the Middle East & Africa

Market Analyst Overview

The market is witnessing significant growth due to the increasing demand from various industries, including Biopharmaceuticals, Life Sciences Research, Personalized Medicine, Biotechnology, Bioprocessing, and Biomolecules. These reagents play a crucial role in the Separation and Purification processes, used for isolating Target Molecules such as Proteins, Antibodies, Enzymes, and Nucleic acids. Affinity chromatography reagents find extensive applications in Academic Research, Product Standardization, and Regulatory Compliance. Monoclonal Antibodies and Recombinant Proteins are major target molecules for these reagents in Biopharmaceutical production, Drug Discovery, and Drug Development.

Furthermore, the market is driven by the increasing research activities in Healthcare, Biotechnology Industry, Cosmetic Industry, Environmental testing, and Chronic diseases. The aging population also contributes to the growth of this market, as the demand for High Purity Biopharmaceuticals and complex Biomolecules increases. Affinity chromatography techniques utilize Ligands, Columns, Magnetic Beads, and Reagents and Consumables for efficient Separation and Purification. The market is expected to grow further due to the customizable nature of these reagents, catering to the specific needs of various industries and applications.

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What are the Key Data Covered in this Market Report?

• CAGR of the market during the forecast period
• Detailed information on factors that will drive the market growth and forecasting of the market between 2024 and 2028
• Precise estimation of the size of the market size and its contribution to the parent market
• Accurate predictions about upcoming market trends and analysis and changes in consumer behavior
• Growth of the market industry across Europe, North America, APAC, South America, and Middle East and Africa
• Thorough market growth analysis of the market's competitive landscape and detailed information about companies
• Comprehensive market analysis and report on the factors that will challenge the market research and growth of market companies

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