Orthobiologics Market Size 2024-2028

The orthobiologics market size is estimated to grow by USD 2.77 billion at a CAGR of 7.75% between 2023 and 2028. The market's growth is influenced by various factors, including the increasing prevalence of orthopedic disorders, especially among the aging population. Additionally, there is a growing focus on reducing orthopedic surgeries with orthopedic surgical robots, and the market is witnessing a rise in approvals and clearances for such products. However, the market faces challenges, such as high costs and inadequate reimbursements for such products and procedures, concerns associated with their use, and stringent regulations. Despite these challenges, the market is experiencing positive market growth and forecasting, including the development of new products such as orthopedic implants, emerging technological innovations, and the rising popularity of orthobiologics.

What will be the Size of the Orthobiologics Market During the Forecast Period?

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Orthobiologics Market Segmentation

The orthobiologics market research report provides comprehensive data (region-wise segment analysis), with forecasts and estimates in "USD billion" for the period 2024-2028, as well as historical data from 2018 - 2022 for the following segments.

• Application Outlook
  • Spinal fusion
  • Reconstructive surgery
  • Trauma repair
  • Others
• ProductOutlook 
  • Bone graft substitutes
  • Viscosupplementation
  • Stem cells
• Region Outlook 
  • North America
    • The U.S.
    • Canada
  • Europe
    • The U.K.
    • Germany
    • France
    • Rest of Europe
  • Asia
    • China
    • India
  • Rest of the World
    • Brazil
    • Argentina
    • Australia 

By Application

The market share by the spinal fusion segment will be significant during the forecast period. Spinal fusion or spinal arthrodesis is a technique that permanently joins two or more vertebrae in the spine to increase stability, repair a deformity, or relieve discomfort. Patients with spinal disorders such as spinal abnormalities, spinal weakness or instability, and herniated discs can benefit from this therapy. As a result, orthobiologics improve the efficacy of spinal fusion surgeries and bone biopsy by healing the targeted site. Such orthobiologic advantages in spinal fusion procedures will drive orthobiologic demand over the projection period.

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The spinal fusion segment accounted for USD 2.44 billion in 2018. The higher prevalence of spine-related issues is anticipated to drive the spine fusion application segment in the market. Scoliosis affects 2-3 percent of the population, or around six to nine million persons in the United States, according to data from the National Scoliosis Foundation. People in their thirties and fifties are more prone to it. Above mentioned spinal disorders are generally treated with spinal fusion devices in addition to procedures. Thus, a higher prevalence of such diseases is expected to boost the growth of the spinal fusion segment in the orthobiologics market.

Regional Analysis

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North America is estimated to contribute 41% to the growth of the global market during the forecast period. Technavio's analysts have elaborately explained the regional trends and drivers that will shape the market during the forecast period. North America dominated the market and is expected to maintain its position during the projection period due to the presence of a well-established healthcare system that provides high-quality orthobiologics. Obesity and an increase in the prevalence of arthritis have increased the demand for minimally invasive procedures such as bone replacement and bone grafting. The increase in sports injuries across North America is also a major factor driving orthobiologics market growth. 

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Orthobiologics Market Dynamics

Orthobiologics refers to a category of medical treatments that utilize the body's own cells, tissues, and biochemicals to promote bone repair and regeneration. These innovative solutions have gained significant attention in the medical community due to their potential to address various orthopedic conditions, including bone diseases, bone tumors, bone infections, traumas, bone lesions, and bone fractures. Orthobiologics has revolutionized the field of regenerative medicine by offering alternatives to traditional orthopedic procedures. Biocomposites, bone grafts and substitutes, and specialized products like fare some of the popular orthobiologic solutions. The market for orthobiologics is driven by the increasing prevalence of bone-related conditions, advancements in medical technology, and the growing demand for minimally invasive procedures. Specialty clinics, orthopedic hospitals, and leading medical device manufacturers like Medtronic and Stryker are actively investing in the development and commercialization of orthobiologic products. Applications of orthobiologics extend beyond orthopedics, with sports science physicians and pain specialists also adopting these solutions to treat joint injuries, muscle injuries, chronic illnesses, and traumas caused by accidents or sports activities.

This field is a key component of regenerative medicine and is gaining significant attention due to its potential to improve outcomes in various orthopedic procedures. The market is driven by the increasing prevalence of bone diseases, bone tumors, bone infections, traumas, bone lesions, and bone fractures. Biocomposites, bone graft substitutes, and Prosidyan are some of the key orthobiologic products used in the treatment of these conditions. Specialty clinics and major orthopedic companies, such as Medtronic and Stryker, are at the forefront of developing and marketing these innovative solutions. The market is also being fueled by the growing number of maxillofacial fractures caused by automobile accidents and sports injuries. Joint injuries, muscle injuries, chronic illnesses, and pain medication are other areas where orthobiologics are making a significant impact. The future looks promising as research continues to uncover new applications and advancements in this field. Our researchers analyzed the market research and growth data with 2023  as the base year, along with the key market growth analysis, trends, and challenges. A holistic analysis of drivers, trends, and challenges will help companies refine their marketing strategies to gain a competitive advantage.

Key Market Driver

The increasing prevalence of orthopedic disorders coupled with an aging population is a key factor in the growth of the market. There has been an increase in the number of orthopedic disorders across the world over the last decade. Limited physical activity and eating habits can negatively influence the body's homeostasis. This issue worsens with age, putting most persons aged 60 and up vulnerable to orthopedic disorders such as arthritis. Further, orthobiologics, including fibergaft bone graft substitutes, play a vital role in treating bone tumors, infections, bone lesions, and bone fractures, offering innovative solutions to enhance bone healing and regeneration in orthopedic procedures.

Further, orthobiologic products utilized by sports science physicians offer innovative solutions for treating joint injuries, providing alternatives to traditional pain medication and facilitating natural healing processes in orthopedic care. According to the CDC, approximately 65.6% of persons aged 65 and up will visit dental surgeons in 2023. Due to the rise in the prevalence of orthopedic problems, orthobiologics are required for the fixation or binding of joint disorders. Thus, the increasing number of orthopedic disorders will increase the demand and thus drive orthobiologics market growth.

Significant Market Trends

The increase in the development of new products is a key trend shaping the market's growth. These product launches will encourage other market players to invest in developing advanced products to maintain their position in the market. Therefore, the introduction of new products will support the revenue inflow in the market during the forecast period. Many companies offering orthobiologics, such as Bioventus LLC, are focusing on the development of new products to cater to customers with specific requirements.

Furthermore, the rise in popularity of orthobiologics will drive market growth. Orthobiologics therapy focuses on using the healing and rejuvenating properties of the body's own cells for the repair of damaged tissues. Some of the innovative orthobiologics options which are helpful in the treatment of osteoarthritis include platelet-rich plasma (PRP), adipose tissue-derived mesenchymal stem cells (ADMSC), bone marrow concentrate (BMC), autologous chondrocyte implantation (ACI), and autologous conditioned serum. The availability of such products has resulted in preventing operative procedures such as knee arthroplasty for the treatment of osteoarthritis. This, in turn, is anticipated to boost orthobiologics market growth over the forecast period.

Major Market Challenge

The high costs and inadequate reimbursements for products and procedures are major challenges to orthobiologics market growth. The growing geriatric population, combined with a growth in the number of orthopedic illnesses, has boosted the demand. Advanced ortho biologics products are widely available on the market, particularly in developed countries like the United States. However, the expensive cost of these products prevents them from being widely adopted in emerging and underdeveloped economies. 

For instance, reimbursement is complex in the US due to stringent FDA regulations and the multi-payor system. The high costs of such products, such as new bone grafts, also make reimbursement challenging, leading to low adoption rates in economically depressed countries. Therefore, for manufacturers to be successful, the development of a comprehensive plan for reimbursement before obtaining FDA approval becomes essential. The impact of these factors, however, is expected to reduce in the near future, as many manufacturers are planning to develop affordable products. 

Customer Landscape

The orthobiologics market forecasting report includes the adoption lifecycle of the market, covering from the innovator's stage to the laggard's stage. It focuses on adoption rates in different regions based on penetration. Furthermore, the orthobiologics market growth analysis report also includes key purchase criteria and drivers of price sensitivity to help companies evaluate and develop their market forecasting and growth strategies.

 Customer Landscape

Key Orthobiologics Market Companies & Insights

Companies are implementing various strategies, such as strategic alliances, partnerships, mergers and acquisitions, geographical expansion, and product/service launches for orthopedic devices, to enhance their presence in the market. The report also includes detailed analyses of the competitive landscape of the market and information about key companies, including:

Advanced Medical Solutions Group Plc: The company offers orthobiologics solutions that include synthetic bone substitutes, collagen membranes, and bioabsorbable screws.

Advanced Medical Solutions Group Plc, Anika Therapeutics Inc., Arthrex Inc., Bioventus LLC, Globus Medical Inc., Institut Straumann AG, Integra Lifesciences Corp., Johnson and Johnson Services Inc., Kuros Biosciences AG, Medtronic Plc, MTF Biologics, Nuvasive Inc., Orthofix Medical Inc., OrthoPediatrics Corp., ROYAL BIOLOGICS, RTI Surgical Inc., Smith and Nephew plc, Stryker Corp., Xtant Medical Holdings Inc., and Zimmer Biomet Holdings Inc.

Qualitative and quantitative analysis of companies has been conducted to help clients understand the wider business environment as well as the strengths and weaknesses of key market players. Data is qualitatively analyzed to categorize companies as pure play, category-focused, industry-focused, and diversified; it is quantitatively analyzed to categorize companies as dominant, leading, strong, tentative, and weak.

Market Analyst Overview

Orthobiologics refer to a range of biological agents and materials and orthopedic devices used to promote the regeneration of bone and other tissues in the musculoskeletal system. These innovative products find extensive applications in the treatment of various bone conditions, including bone diseases, bone tumors, bone infections, traumas, bone lesions, bone biopsy and bone fractures. Orthobiologics market encompasses stem cell-based allografts, viscosupplements, bone growth factors, synthetic bone substitutes, and cellular allografts, among others. The increasing prevalence of musculoskeletal diseases such as osteoarthritis, osteoporosis, and bone injuries fuels the demand for orthobiologics. Orthopedic procedures, such as spinal fusion, maxillofacial & dental, soft tissue repair, and reconstructive & fracture surgery, are significant end-users of orthobiologics. Orthobiologic products find applications in the treatment of various bone conditions, including bone fractures from automobile accidents and maxillofacial fractures. INFUSE bone growth factors and other bone growth factors are popular orthobiologic products. Vaccination coverage and regulatory approvals significantly impact orthobiologics market growth.

Orthobiologic therapies have revolutionized the field of musculoskeletal disorders, providing innovative solutions for various conditions. These advanced treatments, driven by biotechnology, include stem cell therapy, platelet-rich plasma (PRP), hyaluronic acid derivatives, and viscosupplementation products. Orthopedic clinics and ambulatory care centers increasingly utilize these therapies for arthroscopy, osteoarthritis and degenerative arthritis, fracture recovery, and soft tissue injuries. Stem cell therapy harnesses the body's natural healing abilities, while PRP accelerates tissue repair using a patient's own platelets. Hyaluronic acid, a key component in viscosupplementation, lubricates joints and aids in shock absorption. Other synthetic orthobiologics, such as demineralized bone matrix, bone morphogenetic protein, and bone marrow aspirate concentrate, promote bone growth and tissue regeneration. Bioactive coatings are also gaining popularity in orthopedics for their role in enhancing implant integration. Applications of orthobiologics extend to maxillofacial and dental procedures, making them an essential tool for researchers and academic institutes, as well as dental clinics and facilities. The versatility of these therapies continues to expand, offering new hope for patients with broken bones and other musculoskeletal conditions.

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What are the Key Data Covered in this Orthobiologics Market Research Report?

• CAGR of the market during the forecast period
• Detailed information on factors that will drive the growth of the between 2024 and 2028
• Precise estimation of the size of the market and its contribution in focus to the parent market
• Detailed analysis of customer landscape covering diver of price sensitivity, adoption of the lifecycle, and key purchase criteria 
• Companies landscape comparing criticality of inputs and factors of differentiation
• Exclusive Matrix on companies position and classification
• Accurate predictions about upcoming trends and changes in consumer behavior
• Growth of the market across North America, Europe, Asia, and Rest of World (ROW)
• Thorough analysis of the market's competitive landscape and detailed information about companies
• Comprehensive analysis of factors that will challenge the growth of companies